E-mail address: [email protected]
Position: Research Assistant Professor
Education: Ph.D. in Cancer Pathology, Fudan University, China
As a cancer pathologist, my research interests center on the molecular basis of cancer metastasis. Extracellular proteolysis, cell adhesion and cell mobility are what cancer cells rely on to invade and spread. Non-coding small RNAs seem to be deeply involved with the regulation of these processes. One of my current efforts is to delineate the roles of miR-146a and miR-452 and their mechanism of action in oral cancer progression and metastasis, with a wide variety of approaches from genetic engineering, molecular and cell biology, biochemistry, histopathology, live cell imaging and small animal imaging. I also seek to develop better cellular and animal models for metastasis studies.
1: Shi Z, Johnson JJ, Stack MS. Fluorescence In Situ Hybridization for MicroRNA Detection in Archived Oral Cancer Tissues. J Oncol. 2012;2012:903581. doi:10.1155/2012/903581.
2: Shi Z, Liu Y, Johnson JJ, Stack MS. Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas. Mol Cell Biochem. 2011 Nov;357(1-2):151-61. doi: 10.1007/s11010-011-0885-3.
3: Jiang R, Shi Z, Johnson JJ, Liu Y, Stack MS. Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma. J Biol Chem. 2011 Mar 18;286(11):9127-35. doi: 10.1074/jbc.M110.191361.
4: Shi Z, Stack MS. Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma. Histol Histopathol. 2010 Jul;25(7):917-32.